The investment needed in global water infrastructure is significant.Infrastructures in water supply and sanitation alone are expected to require USD 6.7 trillion by 2050.These infrastructures must provide investment justifications when seeking funding from disbursement sources, in competition with other services (such as health, education, transpor
A proposed molecular mechanism for pathogenesis of severe RNA-viral pulmonary infections [version 1; peer review: 2 approved]
Background: Certain riboviruses can cause severe pulmonary complications leading to death in some infected patients.We propose that DNA damage induced-apoptosis accelerates viral release, triggered by depletion of host RNA binding proteins (RBPs) from nuclear RNA bound to replicating viral sequences.Methods: Information theory-based analysis of int
Mining Milk for Factors which Increase the Adherence of Bifidobacterium longum subsp. infantis to Intestinal Cells
Bifidobacteria play a vital role in human nutrition and health by shaping and maintaining the gut ecosystem.In order to exert a beneficial effect, a sufficient population of bifidobacteria must colonise the host.In this study, we developed a miniaturised high-throughput in vitro assay for assessing the colonising ability of bacterial strains in hum
Heterologous versus homologous COVID-19 booster vaccinations for adults: systematic review with meta-analysis and trial sequential analysis of randomised clinical trials
Abstract Background To Batteries - Chargers combat coronavirus disease 2019 (COVID-19), booster vaccination strategies are important.However, the optimal administration of booster vaccine platforms remains unclear.Herein, we aimed to assess the benefits and harms of three or four heterologous versus homologous booster regimens.Methods From November